Symbol
Name
ID

Ifng
interferon gamma
MGI:107656

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes

Decreased circulating IgA level

Decreased circulating IgG level

Decreased circulating IgG2 level

Defective B cell differentiation

Abnormal B cell count

Decreased proportion of CD4-positive helper T cells

T lymphocytopenia

Lymphopenia

Leukocytosis

Abnormality of neutrophils

Hemophagocytosis

Leukemia

Acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemias

Sinusitis

Stomatitis

Recurrent pharyngitis

Pericarditis

Pulmonary lymphangiomyomatosis

Lymphadenopathy

Mediastinal lymphadenopathy

Hypoplasia of the thymus

Splenic rupture

Splenomegaly

Hepatosplenomegaly

Gastrointestinal inflammation

Recurrent gastroenteritis

Acute hepatitis

Chronic hepatitis

Liver abscess

Otitis media

Inflammatory abnormality of the eye

Recurrent urinary tract infections

Fasciitis

Inflammatory abnormality of the skin

Eczematoid dermatitis

Skin rash

Maculopapular exanthema

Myositis

Pneumonia

Anti-citrullinated protein antibody positivity

Rheumatoid factor positive

Sepsis

BCGitis

BCGosis

Recurrent infections

Recurrent respiratory infections

Recurrent lower respiratory tract infections

Recurrent bronchitis

Meningitis

Disease(s) Associated with IFNG

acute lymphoblastic leukemia

ataxia telangiectasia

chronic granulomatous disease

factor VIII deficiency

graft-versus-host disease

immunodeficiency 69

rheumatoid arthritis

temporal arteritis

tuberous sclerosis 2

vesicoureteral reflux

Mouse Phenotypes

immune system phenotype

myocarditis

abnormal dendritic cell chemotaxis

abnormal macrophage chemotaxis

abnormal diapedesis

increased splenocyte proliferation

peritoneal inflammation

stomach inflammation

abnormal uterine NK cell morphology

increased uterine NK cell number

thymus atrophy

pancreas inflammation

enlarged spleen

abnormal B cell differentiation

increased neutrophil cell number

increased granulocyte number

decreased mature B cell number

decreased pre-B cell number

increased CD8-positive, alpha-beta T cell number

increased NK T cell number

increased T cell number

increased lymphocyte cell number

increased macrophage cell number

increased monocyte cell number

decreased leukocyte cell number

increased leukocyte cell number

abnormal spleen morphology

abnormal spleen red pulp morphology

spleen atrophy

abnormal spleen white pulp morphology

pale spleen

abnormal B cell physiology

abnormal immunoglobulin level

decreased IgA level

decreased IgE level

increased IgE level

increased IgG1 level

decreased IgG2a level

decreased IgG2b level

decreased IgG3 level

decreased IgG level

decreased IgM level

decreased immunoglobulin level

abnormal NK cell physiology

impaired natural killer cell mediated cytotoxicity

abnormal uterine NK cell physiology

abnormal cytotoxic T cell physiology

abnormal T cell activation

abnormal macrophage physiology

abnormal MHC II cell surface expression on macrophages

abnormal circulating cytokine level

abnormal circulating interferon level

increased circulating interleukin-12 level

increased circulating interleukin-6 level

abnormal cytokine level

abnormal lymph node morphology

enlarged mesenteric lymph nodes

abnormal lymph node cell ratio

abnormal adaptive immunity

abnormal dendritic cell physiology

abnormal Langerhans cell physiology

abnormal dendritic cell antigen presentation

abnormal type IV hypersensitivity reaction

decreased susceptibility to type IV hypersensitivity reaction

increased susceptibility to type IV hypersensitivity reaction

abnormal humoral immune response

abnormal cytokine secretion

abnormal interferon-gamma secretion

decreased interferon-gamma secretion

decreased interleukin-10 secretion

increased interleukin-10 secretion

increased interleukin-12 secretion

increased interleukin-17 secretion

increased interleukin-2 secretion

increased interleukin-4 secretion

increased interleukin-5 secretion

abnormal immune tolerance

abnormal susceptibility to autoimmune disorder

decreased susceptibility to autoimmune disorder

decreased susceptibility to autoimmune diabetes

increased susceptibility to experimental autoimmune encephalomyelitis

decreased autoantibody level

decreased anti-nuclear antigen antibody level

decreased anti-double stranded DNA antibody level

abnormal inflammatory response

chronic liver inflammation

decreased inflammatory response

CNS inflammation

liver inflammation

glomerulonephritis

abnormal response to infection

abnormal susceptibility to infection

increased susceptibility to bacterial infection

increased susceptibility to bacterial infection induced morbidity/mortality

decreased susceptibility to parasitic infection induced morbidity/mortality

increased susceptibility to parasitic infection induced morbidity/mortality

increased susceptibility to Herpesvirales infection induced morbidity/mortality

increased susceptibility to Coronaviridae infection induced morbidity/mortality

decreased susceptibility to parasitic infection

increased susceptibility to parasitic infection

increased susceptibility to Herpesvirales infection

increased susceptibility to Coronaviridae infection

abnormal response to transplant

decreased length of allograft survival

Availability

Mouse Genotype

Ifng^tm1.1Hayg/Ifng^tm1.1Hayg

Ifng^tm1Lky/Ifng^tm1Lky

Ifng^tm1Ts/Ifng^tm1Ts

Ifng^tm1Yiw/Ifng^tm1Yiw

Tg(APCS-Ifng)5Imeg/0

Tg(GFAP-tTA)78Pop/0
Tg(tetO-Ifng)184Pop/0

Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli/0

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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